Although rapid progress is being made in many areas of molecular cardiology, issues
pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic …

The adult human heart is an ideal target for regenerative intervention since it does not
functionally restore itself after injury yet has a modest regenerative capacity that could be …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion,
inflammation, vessel injury/repair, wound healing, temperature regulation, digestion …

Recent evidence suggests that the heart possesses a greater regeneration capacity than
previously thought. In the present study, we isolated undifferentiated precursors from the …

Since the first half of the 20th century, experimental embryologists have noted a relationship
between endoderm cells and the development of cardiac tissue from mesoderm. During the …

Expression patterns of Tbx2,-3, and-5 genes were analyzed during chick embryonic heart
development. Transcripts of these three cTbx genes were detected in overlap** patterns …

Cardiac muscle creation during embryogenesis requires extracellular instructive signals that
are regulated precisely in time and space, intersecting with intracellular genetic programs …

Previous studies have identified two signaling interactions regulating cardiac myogenesis in
avians, a hypoblast-derived signal acting on epiblast and mediated by activin or a related …

We previously reported that combined treatment with bone morphogenetic protein-2 (BMP-
2) and fibroblast growth factor-4 (FGF-4) induces cardiogenic events culminating in full …