Systemic chemotherapy remains the backbone of many cancer treatments. Due to its
untargeted nature and the severe side effects it can cause, numerous nanomedicine …

Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an
emerging technology for therapeutic treatment of various malignant tumors. However, the …

Multimodal phototheranostics on the basis of a single molecule with one‐for‐all
characteristics represents a convenient approach for effective cancer treatment. In this …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …

Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …

Nanoparticles need to navigate a complex microenvironment to target cells in solid tumors
after extravasation. Diffusion is currently the accepted primary mechanism for nanoparticle …