Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …

Quantitative views of cellular functions require precise measures of rates of biomolecule
production, especially proteins—the direct effectors of biological processes. Here, we …

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter
cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes …

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …

Human beings are made of~ 50 trillion cells which arise from serial mitotic divisions of a
single cell-the fertilised egg. Remarkably, the early human embryo is often chromosomally …

Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra …