L-type Ca2+ current in ventricular cardiomyocytes
L-type Ca2+ channels are mediators of Ca2+ influx and the regulatory events accompanying
it and are pivotal in the function and dysfunction of ventricular cardiac myocytes. L-type …
it and are pivotal in the function and dysfunction of ventricular cardiac myocytes. L-type …
Regulation of Cardiac L-Type Ca2+ Channel CaV1.2 Via the β-Adrenergic-cAMP-Protein Kinase A Pathway: Old Dogmas, Advances, and New Uncertainties
In the heart, adrenergic stimulation activates the β-adrenergic receptors coupled to the
heterotrimeric stimulatory Gs protein, followed by subsequent activation of adenylyl cyclase …
heterotrimeric stimulatory Gs protein, followed by subsequent activation of adenylyl cyclase …
Trpm4 Gene Invalidation Leads to Cardiac Hypertrophy and Electrophysiological Alterations
Rationale TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart,
particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently …
particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently …
Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700
Y Fu, RE Westenbroek, T Scheuer… - Proceedings of the …, 2014 - National Acad Sciences
L-type calcium (Ca2+) currents conducted by voltage-gated Ca2+ channel CaV1. 2 initiate
excitation–contraction coupling in cardiomyocytes. Upon activation of β-adrenergic …
excitation–contraction coupling in cardiomyocytes. Upon activation of β-adrenergic …
[HTML][HTML] Ryanodine receptor-mediated arrhythmias and sudden cardiac death
LM Blayney, FA Lai - Pharmacology & therapeutics, 2009 - Elsevier
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …
Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability
The insulin IGF-1–PI3K–Akt signaling pathway has been suggested to improve cardiac
inotropism and increase Ca2+ handling through the effects of the protein kinase Akt …
inotropism and increase Ca2+ handling through the effects of the protein kinase Akt …
Ca2+ influx through L-type Ca2+ channels and transient receptor potential channels activates pathological hypertrophy signaling
Common cardiovascular diseases such as hypertension and myocardial infarction require
that myocytes develop greater than normal force to maintain cardiac pump function. This …
that myocytes develop greater than normal force to maintain cardiac pump function. This …
[HTML][HTML] Voltage-and calcium-dependent inactivation in high voltage-gated Ca2+ channels
T Cens, M Rousset, JP Leyris, P Fesquet… - Progress in biophysics …, 2006 - Elsevier
Calcium influx into cardiac myocytes via voltage-gated Ca channels is a key step in initiating
the contractile response. During prolonged depolarizations, toxic Ca2+ overload is …
the contractile response. During prolonged depolarizations, toxic Ca2+ overload is …
There Goes the Neighborhood: Pathological Alterations in T‐Tubule Morphology and Consequences for Cardiomyocyte Ca2+ Handling
T‐tubules are invaginations of the cardiomyocyte membrane into the cell interior which form
a tortuous network. T‐tubules provide proximity between the electrically excitable cell …
a tortuous network. T‐tubules provide proximity between the electrically excitable cell …
Calcium signaling in the heart
DA Terrar - Calcium Signaling, 2020 - Springer
The aim of this chapter is to discuss evidence concerning the many roles of calcium ions, Ca
2+, in cell signaling pathways that control heart function. Before considering details of these …
2+, in cell signaling pathways that control heart function. Before considering details of these …