Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Interactions between the immune and central nervous systems strongly influence brain
health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal …

Background: Inflammation resolution and cardiac repair initiation after myocardial infarction
(MI) require timely activation of reparative signals. Histone lactylation confers macrophage …

Rationale: Recent advancements have brought to light the origins, complexity, and functions
of tissue-resident macrophages. However, in the context of tissue injury or disease, large …

Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …

Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …

Recent advances in cell tracing and sequencing technologies have expanded our
knowledge on leukocyte behavior. As a consequence, inflammatory cells, such as monocyte …