Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Link between antibiotic persistence and antibiotic resistance in bacterial pathogens

W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2022 - frontiersin.org
Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in
which a bacterial cell becomes insensitive to one (or even) more antibiotic (s). However, the …

Viable but non‐culturable and persistence describe the same bacterial stress state

JS Kim, N Chowdhury, R Yamasaki… - Environmental …, 2018 - Wiley Online Library
Bacteria are often thought of as having two dormant phenotypes: the viable but non‐
culturable (VBNC) state and the persister state. Here we investigate the relatedness of the …

ppGpp ribosome dimerization model for bacterial persister formation and resuscitation

S Song, TK Wood - Biochemical and biophysical research communications, 2020 - Elsevier
Stress is ubiquitous for bacteria and can convert a subpopulation of cells into a dormant
state known as persistence, in which cells are tolerant to antimicrobials. These cells revive …

[HTML][HTML] Forming and waking dormant cells: The ppGpp ribosome dimerization persister model

TK Wood, S Song - Biofilm, 2020 - Elsevier
Procaryotes starve and face myriad stresses. The bulk population actively resists the stress,
but a small population weathers the stress by entering a resting stage known as persistence …

Persister cells resuscitate using membrane sensors that activate chemotaxis, lower cAMP levels, and revive ribosomes

R Yamasaki, S Song, MJ Benedik, TK Wood - Iscience, 2020 - cell.com
Persistence, the stress-tolerant state, is arguably the most vital phenotype since nearly all
cells experience nutrient stress, which causes a sub-population to become dormant …

Flow-cytometry analysis reveals persister resuscitation characteristics

SG Mohiuddin, P Kavousi, MA Orman - BMC microbiology, 2020 - Springer
Background Persisters and viable but non-culturable (VBNC) cells are two phenotypic
variants known to be highly tolerant to antibiotics. Although both cell types are stained as …

Ribosome dependence of persister cell formation and resuscitation

TK Wood, S Song, R Yamasaki - Journal of Microbiology, 2019 - Springer
Since most bacterial cells are starving, they must enter a resting stage. Persister is the term
used for metabolically-dormant cells that are not spores, and these cells arise from stress …

Bacterial memory in antibiotic resistance evolution and nanotechnology in evolutionary biology

C Zhang, Y Kong, Q **ang, Y Ma, Q Guo - Iscience, 2023 - cell.com
Bacterial memory refers to the phenomenon in which past experiences influence current
behaviors in response to changing environments. It serves as a crucial process that enables …

[HTML][HTML] A quantitative survey of bacterial persistence in the presence of antibiotics: towards antipersister antimicrobial discovery

JE Salcedo-Sora, DB Kell - Antibiotics, 2020 - mdpi.com
Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …