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Bacterial persisters: molecular mechanisms and therapeutic development
H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
Link between antibiotic persistence and antibiotic resistance in bacterial pathogens
W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2022 - frontiersin.org
Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in
which a bacterial cell becomes insensitive to one (or even) more antibiotic (s). However, the …
which a bacterial cell becomes insensitive to one (or even) more antibiotic (s). However, the …
Viable but non‐culturable and persistence describe the same bacterial stress state
Bacteria are often thought of as having two dormant phenotypes: the viable but non‐
culturable (VBNC) state and the persister state. Here we investigate the relatedness of the …
culturable (VBNC) state and the persister state. Here we investigate the relatedness of the …
ppGpp ribosome dimerization model for bacterial persister formation and resuscitation
Stress is ubiquitous for bacteria and can convert a subpopulation of cells into a dormant
state known as persistence, in which cells are tolerant to antimicrobials. These cells revive …
state known as persistence, in which cells are tolerant to antimicrobials. These cells revive …
[HTML][HTML] Forming and waking dormant cells: The ppGpp ribosome dimerization persister model
Procaryotes starve and face myriad stresses. The bulk population actively resists the stress,
but a small population weathers the stress by entering a resting stage known as persistence …
but a small population weathers the stress by entering a resting stage known as persistence …
Persister cells resuscitate using membrane sensors that activate chemotaxis, lower cAMP levels, and revive ribosomes
Persistence, the stress-tolerant state, is arguably the most vital phenotype since nearly all
cells experience nutrient stress, which causes a sub-population to become dormant …
cells experience nutrient stress, which causes a sub-population to become dormant …
Flow-cytometry analysis reveals persister resuscitation characteristics
Background Persisters and viable but non-culturable (VBNC) cells are two phenotypic
variants known to be highly tolerant to antibiotics. Although both cell types are stained as …
variants known to be highly tolerant to antibiotics. Although both cell types are stained as …
Ribosome dependence of persister cell formation and resuscitation
Since most bacterial cells are starving, they must enter a resting stage. Persister is the term
used for metabolically-dormant cells that are not spores, and these cells arise from stress …
used for metabolically-dormant cells that are not spores, and these cells arise from stress …
Bacterial memory in antibiotic resistance evolution and nanotechnology in evolutionary biology
C Zhang, Y Kong, Q **ang, Y Ma, Q Guo - Iscience, 2023 - cell.com
Bacterial memory refers to the phenomenon in which past experiences influence current
behaviors in response to changing environments. It serves as a crucial process that enables …
behaviors in response to changing environments. It serves as a crucial process that enables …
[HTML][HTML] A quantitative survey of bacterial persistence in the presence of antibiotics: towards antipersister antimicrobial discovery
JE Salcedo-Sora, DB Kell - Antibiotics, 2020 - mdpi.com
Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …