The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
S Cambier, M Gouwy, P Proost - Cellular & Molecular Immunology, 2023 - nature.com
Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
Key chemokines direct migration of immune cells in solid tumors
Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …
(TME), and interaction with other immune cells are controlled by their directed migration …
[HTML][HTML] Role of the CXCL8-CXCR1/2 axis in cancer and inflammatory diseases
H Ha, B Debnath, N Neamati - Theranostics, 2017 - ncbi.nlm.nih.gov
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …
The role of tumor-associated neutrophils in colorectal cancer
R Mizuno, K Kawada, Y Itatani, R Ogawa… - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and
the number of CRC patients is increasing progressively. Despite the improvement of the …
the number of CRC patients is increasing progressively. Despite the improvement of the …
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Y Cheng, F Mo, Q Li, X Han, H Shi, S Chen, Y Wei… - Molecular cancer, 2021 - Springer
Background Drug-resistance and severe side effects of chemotherapeutic agents result in
unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role …
unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role …
Emerging cytokine networks in colorectal cancer
Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …
CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target
W Zhang, H Wang, M Sun, X Deng, X Wu… - Cancer …, 2020 - Wiley Online Library
The components of the tumor microenvironment (TME) in solid tumors, especially
chemokines, are currently attracting much attention from scientists. C‐X‐C motif chemokine …
chemokines, are currently attracting much attention from scientists. C‐X‐C motif chemokine …
[HTML][HTML] The CXCL8-CXCR1/2 pathways in cancer
Persistent infection or chronic inflammation contributes significantly to tumourigenesis and
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …
CXCR2 receptor: regulation of expression, signal transduction, and involvement in cancer
J Korbecki, P Kupnicka, M Chlubek, J Gorący… - International Journal of …, 2022 - mdpi.com
Chemokines are a group of about 50 chemotactic cytokines crucial for the migration of
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …
Neutrophils: important contributors to tumor progression and metastasis
A Swierczak, KA Mouchemore, JA Hamilton… - Cancer and Metastasis …, 2015 - Springer
The presence of neutrophils in tumors has traditionally been considered to be indicative of a
failed immune response against cancers. However, there is now evidence showing that …
failed immune response against cancers. However, there is now evidence showing that …