Challenges for molecular magnetic resonance imaging

E Terreno, DD Castelli, A Viale, S Aime - Chemical reviews, 2010 - ACS Publications
Challenges for Molecular Magnetic Resonance Imaging | Chemical Reviews ACS ACS
Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications. Most …

Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy

JH Ardenkjaer‐Larsen, GS Boebinger… - Angewandte Chemie …, 2015 - Wiley Online Library
In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

J Kurhanewicz, DB Vigneron, K Brindle… - Neoplasia, 2011 - Elsevier
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

[HTML][HTML] Quantifying normal human brain metabolism using hyperpolarized [1–13C] pyruvate and magnetic resonance imaging

JT Grist, MA McLean, F Riemer, RF Schulte, SS Deen… - Neuroimage, 2019 - Elsevier
Abstract Hyperpolarized 13 C Magnetic Resonance Imaging (13 C-MRI) provides a highly
sensitive tool to probe tissue metabolism in vivo and has recently been translated into …

Accelerated MR spectroscopic imaging—a review of current and emerging techniques

W Bogner, R Otazo, A Henning - NMR in Biomedicine, 2021 - Wiley Online Library
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …

IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1‐13C]pyruvate

F Wiesinger, E Weidl, MI Menzel… - Magnetic resonance …, 2012 - Wiley Online Library
Abstract Metabolic imaging with hyperpolarized [1‐13C] pyruvate offers the unique
opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust …

Hyperpolarized magnetic resonance as a sensitive detector of metabolic function

A Comment, ME Merritt - Biochemistry, 2014 - ACS Publications
Hyperpolarized magnetic resonance allows for noninvasive measurements of biochemical
reactions in vivo. Although this technique provides a unique tool for assaying enzymatic …

Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients

PEZ Larson, HY Chen, JW Gordon, N Korn… - NMR in …, 2018 - Wiley Online Library
MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to
provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this …

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors

I Park, PEZ Larson, ML Zierhut, S Hu, R Bok… - Neuro …, 2010 - academic.oup.com
In order to compare in vivo metabolism between malignant gliomas and normal brain, 13C
magnetic resonance (MR) spectroscopic imaging data were acquired from rats with human …

Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies

PEZ Larson, S Hu, M Lustig, AB Kerr… - Magnetic resonance …, 2011 - Wiley Online Library
Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre‐
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …