[HTML][HTML] Bone Morphogenetic Protein (BMP) signaling in development and human diseases
Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …
[HTML][HTML] Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling
M Hussain, C Xu, M Lu, X Wu, L Tang, X Wu - Biochimica et Biophysica …, 2017 - Elsevier
Embryonic lung development requires reciprocal endodermal-mesodermal interactions;
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …
[HTML][HTML] In utero exposures to electronic-cigarette aerosols impair the Wnt signaling during mouse lung development
A Noël, S Hansen, A Zaman… - … of Physiology-Lung …, 2020 - journals.physiology.org
Currently, more than 9 million American adults, including women of childbearing age, use
electronic-cigarettes (e-cigs). Further, the prevalence of maternal va** now approaching …
electronic-cigarettes (e-cigs). Further, the prevalence of maternal va** now approaching …
Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung-versus thyroid-lineage specification
The in vitro-directed differentiation of pluripotent stem cells (PSCs) through stimulation of
developmental signaling pathways can generate mature somatic cell types for basic …
developmental signaling pathways can generate mature somatic cell types for basic …
An eye on the Wnt inhibitory factor Wif1
The coordinated interplay between extrinsic activating and repressing cell signaling
molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is …
molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is …
Hippo and TGF-β interplay in the lung field
A Saito, T Nagase - American Journal of Physiology-Lung …, 2015 - journals.physiology.org
The Hippo pathway is comprised of a kinase cascade that involves mammalian Ste20-like
serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads …
serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads …
Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
A Conidi, S Cazzola, K Beets, K Coddens… - Cytokine & growth factor …, 2011 - Elsevier
Signaling by the many ligands of the TGFβ family strongly converges towards only five
receptor-activated, intracellular Smad proteins, which fall into two classes ie Smad2/3 and …
receptor-activated, intracellular Smad proteins, which fall into two classes ie Smad2/3 and …
Branch mode selection during early lung development
Many organs of higher organisms, such as the vascular system, lung, kidney, pancreas, liver
and glands, are heavily branched structures. The branching process during lung …
and glands, are heavily branched structures. The branching process during lung …
Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4enhancer
Background Reciprocal interactions between lung mesenchymal and epithelial cells play
essential roles in lung organogenesis and homeostasis. Although the molecular markers …
essential roles in lung organogenesis and homeostasis. Although the molecular markers …
Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair
Signaling by Bone Morphogenetic Proteins (BMP) has been implicated in early lung
development, adult lung homeostasis and tissue-injury repair. However, the precise …
development, adult lung homeostasis and tissue-injury repair. However, the precise …