Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely im**e on histone amino …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

Histone acetylation regulates many cellular processes, and specific acetylation marks, either
singly or in combination, produce distinct outcomes. For example, the acetylation pattern on …

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

Mechanisms governing the maintenance of blood-producing hematopoietic stem and
multipotent progenitor cells (HSPCs) are incompletely understood, particularly those …

Double-stranded RNA induces potent and specific gene silencing through a process
referred to as RNA interference (RNAi) or posttranscriptional gene silencing (PTGS). RNAi is …

Acetylation of the [var epsilon]-amino group of a lysine residue was first discovered with
histones in 1968, but the responsible enzymes, histone acetyltransferases and …

Eukaryotic genomes are packaged into nucleosomes whose position and chemical
modification state can profoundly influence regulation of gene expression. We profiled …