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Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing
CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past
decade and holds great promise for the treatment of human genetic diseases. Here we …
decade and holds great promise for the treatment of human genetic diseases. Here we …
Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver
disease and the prevalence is rising, especially in women. Although during reproductive …
disease and the prevalence is rising, especially in women. Although during reproductive …
CRISPR gene therapy: applications, limitations, and implications for the future
A series of recent discoveries harnessing the adaptive immune system of prokaryotes to
perform targeted genome editing is having a transformative influence across the biological …
perform targeted genome editing is having a transformative influence across the biological …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer
Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 editing of
immune checkpoint genes could improve the efficacy of T cell therapy, but the first necessary …
immune checkpoint genes could improve the efficacy of T cell therapy, but the first necessary …
Nanoparticle delivery of CRISPR/Cas9 for genome editing
The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-
associated system (Cas) gene-editing system represents a promising tool for genome …
associated system (Cas) gene-editing system represents a promising tool for genome …
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification in
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Abstract N 6-methyladenosine (m6A), the most prevalent internal RNA modification on
mammalian messenger RNAs, regulates the fates and functions of modified transcripts …
mammalian messenger RNAs, regulates the fates and functions of modified transcripts …
Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids
Human organoid systems recapitulate in vivo organ architecture yet fail to capture complex
pathologies such as inflammation and fibrosis. Here, using 11 different healthy and …
pathologies such as inflammation and fibrosis. Here, using 11 different healthy and …