While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …

Chemotherapy has been a conventional paradigm for cancer treatment, and multifarious
chemotherapeutic drugs have been widely employed for decades with significant …

Ferroptosis is a new form of regulated cell death that is mediated by intracellular iron and
ester oxygenase, and glutathione-dependent lipid hydroperoxidase glutathione peroxidase …

Lysosome-mediated autophagy and caspase-dependent apoptosis are dynamic processes
that maintain cellular homeostasis, ensuring cell health and functionality. The intricate …

As traditional strategies for cancer treatment, some chemotherapy agents, such as
doxorubicin, oxaliplatin, cyclophosphamide, bortezomib, and paclitaxel exert their anti-tumor …

Background Recently, the US Food and Drug Administration (FDA) has approved immune
checkpoint blockade (ICB) for treating cancer patients with tumor mutation burden (TMB)> …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

The search for immunostimulatory drugs applicable to cancer immunotherapy may profit
from target‐agnostic methods in which agents are screened for their functional impact on …

Colorectal cancer (CRC) ranks as the third common and the fourth lethal cancer type
worldwide. Immune checkpoint blockade therapy demonstrates great efficacy in a subset of …

Background Pharmacological autophagy enhancement constitutes a preclinically validated
strategy for preventing or treating most major age-associated diseases. Driven by this …