New biologically potent benzimidazole‐based‐triazole derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors along with molecular docking study
A series of fifteen hybrid analogs (1–15) based on benzimidazole bearing triazole skeleton
were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile. All the …
were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile. All the …
New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with …
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
Novel Mannich bases derived from 1, 2, 4-triazoles: Design, synthesis, characterization, and glutathione S-transferase inhibition properties investigations
The reaction of variously substituted 1, 2, 4-triazole derivatives with morpholine and
formaldehyde represents an efficient and easy-to-set synthetic entry toward heterocyclic N …
formaldehyde represents an efficient and easy-to-set synthetic entry toward heterocyclic N …
Chalcones reverse the anxiety and convulsive behavior of adult zebrafish
MKA Ferreira, AW da Silva, AL dos Santos Moura… - Epilepsy & Behavior, 2021 - Elsevier
In the treatment of anxiety and seizures, drugs of the benzodiazepine (BZD) class are used,
which act on the Central Nervous System (CNS) through the neurotransmitter gamma …
which act on the Central Nervous System (CNS) through the neurotransmitter gamma …
Synthesis and In Vitro α-Amylase and α-Glucosidase Dual Inhibitory Activities of 1,2,4-Triazole-Bearing bis-Hydrazone Derivatives and Their Molecular Docking …
There is an increasing prevalence of diabetes mellitus throughout the world, and new
compounds are necessary to combat this. The currently available antidiabetic therapies are …
compounds are necessary to combat this. The currently available antidiabetic therapies are …
In silico molecular modeling, neuro-behavioral profile, and toxicity assessment of the essential oil of Ferula gummosa Boiss. As an anti-seizure agent
Abstract Ethnopharmacological relevance Ferula gummosa Boiss., known in Persian as
“Baridje,” belongs to the Apiaceae family. All parts of this plant, especially the root, contain …
“Baridje,” belongs to the Apiaceae family. All parts of this plant, especially the root, contain …
Recent advances in microwave-assisted synthesis and functionalization of 1, 2, 3-and 1, 2, 4-triazoles
DP Franco, L Caruso, NF Nadur… - Current Organic …, 2021 - ingentaconnect.com
Triazoles are five-membered aromatic heterocyclics, which exhibit two isosteric forms (1, 2, 3-
triazoles and 1, 2, 4-triazoles), as well as multiple applications in medicinal, agricultural …
triazoles and 1, 2, 4-triazoles), as well as multiple applications in medicinal, agricultural …
New 1, 2, 4-triazol-3-one derivatives with 4-fluorobenzene: Synthesis, characterization, DFT, antimicrobial-antiproliferative activities and molecular docking study
Abstract (E)-5-(4-fluorobenzyl)-4-((2-fluorobenzylidene) amino)-2, 4-dihydro-3H-1, 2, 4-
triazol-3-one (2F),(E)-5-(4-fluorobenzyl)-4-((3-fluorobenzylidene) amino)-2, 4-dihydro-3H-1 …
triazol-3-one (2F),(E)-5-(4-fluorobenzyl)-4-((3-fluorobenzylidene) amino)-2, 4-dihydro-3H-1 …
Sedative-hypnotic, anxiolytic and possible side effects of Salvia limbata CA Mey. Extracts and the effects of phenological stage and altitude on the rosmarinic acid …
Ethnopharmacological relevance Salvia limbata CA Mey.(Persian name: Maryam Goli-e-
labeh dar) has been used for treating central nervous disorders such as insomnia, anxiety …
labeh dar) has been used for treating central nervous disorders such as insomnia, anxiety …
[HTML][HTML] Identification of 1, 2, 4-triazole-bearing Bis-Schiff base hybrid scaffolds: In vitro and in silico insights to develop promising anti-urease and anti-cancer agents
The present work describes the synthetic procedure of 1, 2, 4-triazole derivatives (1–14)
synthesized efficiently in a single step reaction. Basic skeleton confirmation was achieved …
synthesized efficiently in a single step reaction. Basic skeleton confirmation was achieved …