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Harnessing tumor-associated macrophages as aids for cancer immunotherapy
Cancer immunotherapies that engage immune cells to fight against tumors are proving to be
powerful weapons in combating cancer and are becoming increasingly utilized in the clinics …
powerful weapons in combating cancer and are becoming increasingly utilized in the clinics …
The role of the complement system in cancer
V Afshar-Kharghan - The Journal of clinical investigation, 2017 - jci.org
In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …
against invading pathogens, complement activation also participates in the adaptive …
Complement in cancer: untangling an intricate relationship
In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …
Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery
Murine syngeneic tumor models are critical to novel immuno-based therapy development,
but the molecular and immunologic features of these models are still not clearly defined. The …
but the molecular and immunologic features of these models are still not clearly defined. The …
Innate immune recognition of cancer
The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …
cell priming against tumor-associated antigens has generated renewed interest in the innate …
Complement: a key system for immune surveillance and homeostasis
Nearly a century after the significance of the human complement system was recognized, we
have come to realize that its functions extend far beyond the elimination of microbes …
have come to realize that its functions extend far beyond the elimination of microbes …
Macrophages, innate immunity and cancer: balance, tolerance, and diversity
Smouldering inflammation is a component of the tumor microenvironment and represents
the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a …
the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a …
Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade
The complement system is a critical immune component, yet its role in tumor immune
evasion and CD8+ T cell activation is not clearly defined. Here, we demonstrate that …
evasion and CD8+ T cell activation is not clearly defined. Here, we demonstrate that …
Complement in immune and inflammatory disorders: pathophysiological mechanisms
Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …
the underlying processes can be highly distinct. In recent years, the complement system has …
Complement and its receptors: new insights into human disease
VM Holers - Annual review of immunology, 2014 - annualreviews.org
Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …
architecture of the complement system has been known for decades. Two major roles of …