Silica nanoparticles (SiNPs) are being explored as nanocarriers for therapeutics delivery,
which can address a number of intrinsic drawbacks of therapeutics. To translate laboratory …

The development of nanoparticles (NPs) with potential therapeutic uses represents an area
of vast interest in the scientific community during the last years. Recently, the pandemic …

Abstract Background Copper oxide (CuO) nanoparticles (NPs) are known to trigger
cytotoxicity in a variety of cell models, but the mechanism of cell death remains unknown …

The varied transcriptomic response to nanoparticles has hampered the understanding of the
mechanism of action. Here, by performing a meta-analysis of a large collection of …

There is an urgent need to apply effective, data-driven approaches to reliably predict
engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational …

Abstract Ideally, a Systems Toxicology (ST) approach is aimed at by (eco) toxicologists, ie a
multidisciplinary area incorporating classical toxicological concepts with omics technologies …

Toxicological evaluation of substances in regulation still often relies on animal experiments.
Understanding the substances' mode-of-action is crucial to develop alternative test …

Hazard assessment is the first step in evaluating the potential adverse effects of chemicals.
Traditionally, toxicological assessment has focused on the exposure, overlooking the impact …

Nanomaterials (NMs) offer plenty of novel functionalities. Moreover, their physicochemical
properties can be fine-tuned to meet the needs of specific applications, leading to virtually …

Engineered nanomaterials are a broad class of materials with the potential for breakthrough
applications in many sectors of society not least in medicine. Consequently, safety …