Respiratory syncytial virus (RSV): a scourge from infancy to old age

JA Coultas, R Smyth, PJ Openshaw - Thorax, 2019 - thorax.bmj.com
Respiratory syncytial virus (RSV) is the most common single cause of respiratory
hospitalisation of infants and is the second largest cause of lower respiratory infection …

[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-
induced inflammatory responses are largely responsible for the death of novel coronavirus …

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

KH Antunes, JL Fachi, R de Paula, EF da Silva… - Nature …, 2019 - nature.com
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality
in infants< 2 years-old. Here we describe that high-fiber diet protects mice from RSV …

Disease severity in respiratory syncytial virus infection: role of host genetic variation

A Tahamtan, FS Askari, L Bont… - Reviews in medical …, 2019 - Wiley Online Library
Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and
pneumonia in the pediatric population worldwide. The immunopathology of RSV infection …

Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

KS Carpentier, BJ Davenport, KC Haist, MK McCarthy… - Elife, 2019 - elifesciences.org
The magnitude and duration of vertebrate viremia is a critical determinant of arbovirus
transmission, geographic spread, and disease severity. We find that multiple alphaviruses …

Small animal models of respiratory viral infection related to asthma

M Han, C Rajput, T Ishikawa, CR Jarman, J Lee… - Viruses, 2018 - mdpi.com
Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is
most frequently-detected pathogen; followed by respiratory syncytial virus; …

MARCO+ lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination

KS Carpentier, RM Sheridan, CJ Lucas… - The EMBO …, 2021 - embopress.org
Viremia in the vertebrate host is a major determinant of arboviral reservoir competency,
transmission efficiency, and disease severity. However, immune mechanisms that control …

p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus

D Menendez, J Snipe, J Marzec, CL Innes… - The Journal of Clinical …, 2019 - jci.org
The Toll-like receptor 8 (TLR8) has an important role in innate immune responses to RNA
viral infections, including respiratory syncytial virus (RSV). We previously reported that TLR8 …

The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease

C Ballester-López, TM Conlon, Z Ertüz, FR Greiffo… - …, 2019 - thelancet.com
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is the third leading
cause of death worldwide with no curative therapy. A non-canonical Notch ligand, DNER …

Inter-individual variation in health and disease associated with pulmonary infectious agents

KC Verhein, HL Vellers, SR Kleeberger - Mammalian Genome, 2018 - Springer
Respiratory infectious diseases resulting from bacterial or viral pathogens such as
Mycobacterium tuberculosis, Streptococcus pneumoniae, respiratory syncytial virus (RSV) …