CGRP and its receptors provide new insights into migraine pathophysiology

TW Ho, L Edvinsson, PJ Goadsby - Nature Reviews Neurology, 2010 - nature.com
Over the past 300 years, the migraine field has been dominated by two main theories—the
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …

CGRP ligand and receptor monoclonal antibodies for migraine prevention: evidence review and clinical implications

DW Dodick - Cephalalgia, 2019 - journals.sagepub.com
Background: Monoclonal antibodies that target calcitonin gene-related peptide or the
canonical calcitonin gene-related peptide receptor have emerged as effective and well …

Sex and gender considerations in episodic migraine

SR Ahmad, N Rosendale - Current pain and headache reports, 2022 - Springer
Abstract Purpose of Review We seek to update readers on recent advances in our
understanding of sex and gender in episodic migraine with a two part series. In part 1, we …

[HTML][HTML] Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator

Y Takei, K Inoue, M Ogoshi, T Kawahara, H Bannai… - FEBS letters, 2004 - Elsevier
We have identified cDNA encoding a new member of the adrenomedullin (AM) family, AM2,
for the first time in mammals (mouse, rat and human). The predicted precursor carried …

The myometrium: from excitation to contractions and labour

S Wray, C Prendergast - Smooth Muscle Spontaneous Activity …, 2019 - Springer
We start by describing the functions of the uterus, its structure, both gross and fine,
innervation and blood supply. It is interesting to note the diversity of the female's …

A whole‐genome association study for pig reproductive traits

SK Onteru, B Fan, ZQ Du, DJ Garrick… - Animal …, 2012 - Wiley Online Library
A whole‐genome association study was performed for reproductive traits in commercial
sows using the PorcineSNP60 BeadChip and Bayesian statistical methods. The traits …

Calcitonin gene-related peptide and its role in migraine pathophysiology

U Arulmani, A MaassenVanDenBrink… - European journal of …, 2004 - Elsevier
Migraine is a common neurological disorder that is associated with an increase in plasma
calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from …

Recommendations on the use of anti‐CGRP monoclonal antibodies in children and adolescents

CL Szperka, J VanderPluym, SL Orr… - … : The Journal of …, 2018 - Wiley Online Library
Christina L. Szperka, MD, MSCE; Juliana VanderPluym, MD; Serena L. Orr, MD, MSc;
Christopher B. Oakley, MD; William Qubty, MD; Irene Patniyot, MD; Ana Marissa Lagman …

Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes

H Jeong - Expert opinion on drug metabolism & toxicology, 2010 - Taylor & Francis
Importance of the field: Medication use during pregnancy is prevalent, but pharmacokinetic
information of most drugs used during pregnancy is lacking in spite of known effects of …

Safety profile of erenumab, galcanezumab and fremanezumab in pregnancy and lactation: analysis of the WHO pharmacovigilance database

R Noseda, F Bedussi, C Gobbi, C Zecca… - …, 2021 - journals.sagepub.com
Objective To assess the safety profile of erenumab, galcanezumab and fremanezumab in
pregnancy and lactation. Methods Safety reports of suspected adverse drug reactions were …