Structures and general transport mechanisms by the major facilitator superfamily (MFS)
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …
transporters. MFS transporters are responsible for transporting a broad spectrum of …
Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
Organic cation transporters in health and disease
H Koepsell, LC Daws - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Mechanistic understanding of lanthipeptide biosynthetic enzymes
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …
Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …
The treatment options against infections caused by multiple drug-resistant bacteria are …
Understanding transport by the major facilitator superfamily (MFS): structures pave the way
EM Quistgaard, C Löw, F Guettou… - Nature Reviews Molecular …, 2016 - nature.com
Members of the major facilitator superfamily (MFS) of transport proteins are essential for the
movement of a wide range of substrates across biomembranes. As this transport requires a …
movement of a wide range of substrates across biomembranes. As this transport requires a …
Crystal structure of the human glucose transporter GLUT1
The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes
and is responsible for glucose supply to the brain and other organs. Dysfunctional mutations …
and is responsible for glucose supply to the brain and other organs. Dysfunctional mutations …
Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance
Acinetobacter baumannii is a nosocomial pathogen and gram-negative coccobacillus that is
responsible for opportunistic infections, pneumonia, and infections of the urinary tract …
responsible for opportunistic infections, pneumonia, and infections of the urinary tract …
Shared molecular mechanisms of membrane transporters
D Drew, O Boudker - Annual review of biochemistry, 2016 - annualreviews.org
The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …
the conformational changes that take place during structural isomerization from outward-to …
Structural biology of the major facilitator superfamily transporters
N Yan - Annual review of biophysics, 2015 - annualreviews.org
The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest
secondary transporter family and plays a crucial role in a multitude of physiological …
secondary transporter family and plays a crucial role in a multitude of physiological …