The family of aldehyde dehydrogenases (ALDHs) contains 19 isozymes and is involved in
the oxidation of endogenous and exogenous aldehydes to carboxylic acids, which …

Simple Summary Cancer stem cells (CSCs) are an engine of tumor progression and a
source of tumor therapy resistance and regrowth after treatment. Modern conventional …

Background Chemotherapeutic insensitivity remains a big challenge in prostate cancer
treatment. Recently, increasing evidence has indicated that KLF4 plays a key role in prostate …

The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal
cells and extracellular matrices. The TME plays important regulatory roles in tumor …

Prostate cancer (PCa) is the second most frequent cancer diagnosed in men worldwide.
Among the common treatment options, photodynamic therapy (PDT) is being considered a …

The involvement of prostaglandins in cancer was first observed in human esophageal
carcinoma cells, whose invasive and metastatic potential in nude mice was found to be …

Prostate cancer (PCa) is characterised by androgen dependency. Unfortunately, under anti-
androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges …

Abstract Background Etoposide phosphate (VP-16) is a topoisomerase 2 (TOP2) inhibitor
that demonstrated activity in patients with metastatic castration-resistant prostate cancer …

Resistance to anti-cancer drugs is a major cause of treatment failure. While several
intracellular mechanisms of resistance have been postulated, the role of extrinsic factors in …

Simple Summary Androgen targeted therapy has been foundational in the management of
advanced prostate cancer. Nevertheless, responses to the therapy are found to be seldom …