Carbohydrate-active enzymes (CAZymes) in the gut microbiome

JF Wardman, RK Bains, P Rahfeld… - Nature Reviews …, 2022 - nature.com
The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

[HTML][HTML] ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs

H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - Nature, 2022 - nature.com
The composition of the intestinal microbiome varies considerably between individuals and is
correlated with health. Understanding the extent to which, and how, host genetics …

[HTML][HTML] Host genetic regulation of human gut microbial structural variation

DV Zhernakova, D Wang, L Liu, S Andreu-Sánchez… - Nature, 2024 - nature.com
Although the impact of host genetics on gut microbial diversity and the abundance of specific
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion

CR Bakshani, TO Ojuri, B Pilgaard, J Holck… - Nature …, 2025 - nature.com
Akkermansia muciniphila is a human microbial symbiont residing in the mucosal layer of the
large intestine. Its main carbon source is the highly heterogeneous mucin glycoprotein, and …

Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs

A Wang, RVP Ribeiro, A Ali, E Brambate… - Science Translational …, 2022 - science.org
Donor organ allocation is dependent on ABO matching, restricting the opportunity for some
patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and …

Turning universal O into rare Bombay type blood

I Anso, A Naegeli, JO Cifuente, A Orrantia… - Nature …, 2023 - nature.com
Red blood cell antigens play critical roles in blood transfusion since donor incompatibilities
can be lethal. Recipients with the rare total deficiency in H antigen, the Oh Bombay …

Mucin utilization by gut microbiota: recent advances on characterization of key enzymes

G Raba, AS Luis - Essays in Biochemistry, 2023 - portlandpress.com
The gut microbiota interacts with the host through the mucus that covers and protects the
gastrointestinal epithelium. The main component of the mucus are mucins, glycoproteins …

Improving normothermic machine perfusion and blood transfusion through biocompatible blood silicification

C Lei, Z Li, S Ma, Q Zhang, J Guo, Q Ouyang… - Proceedings of the …, 2024 - pnas.org
The growing world population and increasing life expectancy are driving the need to
improve the quality of blood transfusion, organ transplantation, and preservation. Here, to …

Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules

T Katoh, MN Ojima, M Sakanaka, H Ashida, A Gotoh… - Microorganisms, 2020 - mdpi.com
Certain species of the genus Bifidobacterium represent human symbionts. Many studies
have shown that the establishment of symbiosis with such bifidobacterial species confers …