Endoplasmic reticulum stress and unfolded protein response in breast cancer: the balance between apoptosis and autophagy and its role in drug resistance
L Sisinni, M Pietrafesa, S Lepore, F Maddalena… - International journal of …, 2019 - mdpi.com
The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …
Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential
T Liu, CK Daniels, S Cao - Pharmacology & therapeutics, 2012 - Elsevier
Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone
which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the …
which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the …
Chromosome-wide map** of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast
cancer. The completion of the human genome has allowed the identification of the …
cancer. The completion of the human genome has allowed the identification of the …
Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate
How breast cancer cells respond to the stress of endocrine therapies determines whether
they will acquire a resistant phenotype or execute a cell-death pathway. After a survival …
they will acquire a resistant phenotype or execute a cell-death pathway. After a survival …
Location analysis of estrogen receptor α target promoters reveals that FOXA1 defines a domain of the estrogen response
J Laganière, G Deblois, C Lefebvre… - Proceedings of the …, 2005 - National Acad Sciences
Nuclear receptors can activate diverse biological pathways within a target cell in response to
their cognate ligands, but how this compartmentalization is achieved at the level of gene …
their cognate ligands, but how this compartmentalization is achieved at the level of gene …
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We
conducted a genome-wide association study (GWAS) followed by replication in a combined …
conducted a genome-wide association study (GWAS) followed by replication in a combined …
Discovery of estrogen receptor α target genes and response elements in breast tumor cells
Background Estrogens and their receptors are important in human development, physiology
and disease. In this study, we utilized an integrated genome-wide molecular and …
and disease. In this study, we utilized an integrated genome-wide molecular and …
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
Tamoxifen, a selective oestrogen receptor modulator, has been used in the treatment of all
stages of hormone-responsive breast cancer. However, tamoxifen shows partial oestrogenic …
stages of hormone-responsive breast cancer. However, tamoxifen shows partial oestrogenic …
Estrogen receptor target gene: an evolving concept
Estrogen receptor (ER) functions as a transcription factor to induce gene expression events
sufficient for cell division and breast cancer progression. A significant body of work exists on …
sufficient for cell division and breast cancer progression. A significant body of work exists on …
GREB1 is a critical regulator of hormone dependent breast cancer growth
Background Estrogen plays a central role in breast cancer pathogenesis and many potent
risk factors for the development of the disease can be explained in terms of increased …
risk factors for the development of the disease can be explained in terms of increased …