Targeting apoptosis in cancer therapy
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs
ST Diepstraten, MA Anderson, PE Czabotar… - Nature Reviews …, 2022 - nature.com
Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance
Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …
[HTML][HTML] Apoptosis regulation at the mitochondria membrane level
Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …
AZD4573 is a highly selective CDK9 inhibitor that suppresses MCL-1 and induces apoptosis in hematologic cancer cells
J Cidado, S Boiko, T Proia, D Ferguson… - Clinical cancer …, 2020 - AACR
Abstract Purpose: Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and
potential therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have …
potential therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have …
Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer
Mitochondrial energetics and respiration have emerged as important factors in how cancer
cells respond to or evade apoptotic signals. The study of the functional connection between …
cells respond to or evade apoptotic signals. The study of the functional connection between …
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
N Rosa, H Ivanova, LE Wagner 2nd, J Kale… - Cell Death & …, 2022 - nature.com
Abstract Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …
BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy
P Ramesh, JP Medema - Apoptosis, 2020 - Springer
Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-
regulation of the balance between proliferation and apoptosis contributes to tumor initiation …
regulation of the balance between proliferation and apoptosis contributes to tumor initiation …
Bcl-2 inhibition to overcome resistance to chemo-and immunotherapy
According to the World Health Organization (WHO), cancer is a leading cause of death
worldwide. The identification of novel targets for cancer treatment is an area of intense work …
worldwide. The identification of novel targets for cancer treatment is an area of intense work …
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime
cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while …
cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while …