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Epigenetic modifications in stress response genes associated with childhood trauma
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
Biological embedding of experience: a primer on epigenetics
Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …
life health and well-being. Although extensive correlative data exist supporting the notion …
Exaggerated false positives by popular differential expression methods when analyzing human population samples
When identifying differentially expressed genes between two conditions using human
population RNA-seq samples, we found a phenomenon by permutation analysis: two …
population RNA-seq samples, we found a phenomenon by permutation analysis: two …
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …
Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain
Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …
brain, but efforts have largely focused on cortical brain regions. We therefore created a …
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …
Potential role of DNA methylation as a driver of plastic responses to the environment across cells, organisms, and populations
There is great interest in exploring epigenetic modifications as drivers of adaptive
organismal responses to environmental change. Extending this hypothesis to populations …
organismal responses to environmental change. Extending this hypothesis to populations …