Recent advances in the understanding of the molecular mechanisms underlying cancer
progression have led to the development of novel therapeutic targeting strategies. Aberrant …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

Protein glycosylation is involved in DNA damage. Recently, DNA damage has been
connected with the pathogenesis of heart failure. Cell adhesion associated, oncogene …

The DNA damage response (DDR) safeguards the stable genetic information inheritance by
orchestrating a complex protein network in response to DNA damage. However, this …

RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis
(TLS) and homologous recombination (HR) repair. However, whether and how the …

Background Nutrient limitations often lead to metabolic stress during cancer initiation and
progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly …

Introduction O-GlcNAcylation is a type of reversible post-translational modification on
Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O …

DNA damage in astronauts induced by cosmic radiation poses a major barrier to human
space exploration. Cellular responses and repair of the most lethal DNA double-strand …

The past four decades have witnessed tremendous efforts in deciphering the role of O-linked-
N-acetylglucosaminylation (O-GlcNAcylation) in a plethora of biological processes …