Energy metabolism in mammalian sperm motility

A Amaral - WIREs mechanisms of disease, 2022 - Wiley Online Library
Mammalian sperm, the only cells that achieve their purpose outside their organism of origin,
have to swim vigorously within the female reproductive tract to reach an oocyte. Flagellar …

Sperm metabolism

GA Abruzzese, A Sanchez‐Rodriguez… - Molecular …, 2024 - Wiley Online Library
Bioenergetics plays a crucial role in sperm functions, including motility, capacitation‐related
protein modifications, oocyte recognition and interaction, all of which are essential for …

MAPKs signaling is obligatory for male reproductive function in a development-specific manner

L Kumar, S Solanki, A Jain, M Botts, R Gupta… - … in Reproductive Health, 2024 - frontiersin.org
Mitogen-activated protein kinases (MAPKs) represent widely expressed and evolutionarily
conserved proteins crucial for governing signaling pathways and playing essential roles in …

Capacitation promotes a shift in energy metabolism in murine sperm

M Tourmente, E Sansegundo, E Rial… - Frontiers in Cell and …, 2022 - frontiersin.org
In mammals, sperm acquire fertilization ability after a series of physiological and
biochemical changes, collectively known as capacitation, that occur inside the female …

Viscous loading regulates the flagellar energetics of human and bull sperm

F Yazdan Parast, S Veeraragavan, AS Gaikwad… - Small …, 2024 - Wiley Online Library
The viscoelastic properties of the female reproductive tract influence sperm swimming
behavior, but the exact role of these rheological changes in regulating sperm energetics …

Determination of double-and single-stranded DNA breaks in bovine sperm is predictive of their fertilizing capacity

J Ribas-Maynou, A Delgado-Bermúdez… - Journal of Animal …, 2022 - Springer
Background The analysis of chromatin integrity has become an important determinant of
sperm quality. In frozen-thawed bovine sperm, neither the sequence of post-thaw injury …

Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences

RS Yadav, B Kushawaha, R Dhariya, DK Swain… - Biological Research, 2024 - Springer
Background Exposure of humans and animals to heavy metals is increasing day-by-day;
thus, lead even today remains of significant public health concern. According to CDC, blood …

Bioenergetic changes in response to sperm capacitation and two-way metabolic compensation in a new murine model

M Tourmente, E Sansegundo, E Rial… - Cellular and Molecular …, 2023 - Springer
The acquisition of fertilizing ability by mammalian spermatozoa, known as “capacitation,”
includes processes that depend on particular metabolic pathways. This has led to the …

Capacitation of ram spermatozoa promotes changes in energy metabolism and aquaporin 3 and is affected by individual testosterone variations

P Peris‐Frau, A Sanchez‐Rodriguez, R Velázquez… - …, 2024 - Wiley Online Library
Background Recently, the metabolic pathways involved in energy production and the role of
aquaglyceroporins in capacitation‐associated events have been studied in humans and …

Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice

H Wang, Q Dou, KJ Jeong, J Choi… - Journal of Biological …, 2022 - ASBMB
During epididymal transit, redox remodeling protects mammalian spermatozoa, preparing
them for survival in the subsequent journey to fertilization. However, molecular mechanisms …