Biomarkers for breast cancer immunotherapy: PD-L1, TILs, and beyond

A Rizzo, AD Ricci - Expert opinion on investigational drugs, 2022 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) have recently entered into the
therapeutic scenario of metastatic breast cancer. However, only a proportion of patients …

Triple negative breast cancer treatment options and limitations: future outlook

O Obidiro, G Battogtokh, EO Akala - Pharmaceutics, 2023 - mdpi.com
Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …

[HTML][HTML] Recent therapeutic trends and promising targets in triple negative breast cancer

SY Hwang, S Park, Y Kwon - Pharmacology & therapeutics, 2019 - Elsevier
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy

A Sheikh, S Md, P Kesharwani - Journal of Controlled Release, 2021 - Elsevier
A bird's eye view is now demanded in the area of cancer research to suppress the suffering
of cancer patient and mediate the lack of treatment related to chemotherapy. Chemotherapy …

Immune-based combinations for metastatic triple negative breast cancer in clinical trials: current knowledge and therapeutic prospects

A Rizzo, AD Ricci, L Lanotte, L Lombardi… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Immune checkpoint inhibitor (ICI) monotherapy appears to be effective in a
small cohort of patients with metastatic triple negative breast cancer (mTNBC). This supports …

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

N Verma, Y Vinik, A Saroha, NU Nair, E Ruppin… - Science …, 2020 - science.org
Identification of targeted therapies for TNBC is an urgent medical need. Using a drug
combination screen reliant on synthetic lethal interactions, we identified clinically relevant …

Perspectives on triple-negative breast cancer: current treatment strategies, unmet needs, and potential targets for future therapies

GK Gupta, AL Collier, D Lee, RA Hoefer, V Zheleva… - Cancers, 2020 - mdpi.com
Triple-negative breast cancer (TNBC), characterized by the absence or low expression of
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …

Triple negative breast cancer: Immunogenicity, tumor microenvironment, and immunotherapy

S Loizides, A Constantinidou - Frontiers in genetics, 2023 - frontiersin.org
Triple negative breast cancer (TNBC) is a biologically diverse subtype of breast cancer
characterized by genomic and transcriptional heterogeneity and exhibiting aggressive …

Biodegradable polymers for gene delivery

TJ Thomas, HA Tajmir-Riahi, CKS Pillai - Molecules, 2019 - mdpi.com
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …

Nanotechnology-based siRNA delivery strategies for treatment of triple negative breast cancer

R Chadar, P Kesharwani - International Journal of Pharmaceutics, 2021 - Elsevier
Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by
absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal …