Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Residual cardiovascular risk at low LDL: remnants, lipoprotein (a), and inflammation
Background Current guidelines target low-density lipoprotein cholesterol (LDL-C)
concentrations to reduce atherosclerotic cardiovascular disease (ASCVD) risk, and yet …
concentrations to reduce atherosclerotic cardiovascular disease (ASCVD) risk, and yet …
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from …
Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA),
there is still substantial controversy and uncertainty on the evidence linking PUFA to …
there is still substantial controversy and uncertainty on the evidence linking PUFA to …
[HTML][HTML] Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
Predicting longer-term mortality risk requires collection of clinical data, which is often
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify …
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify …
Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies
P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
Lipids, lipoproteins, and metabolites and risk of myocardial infarction and stroke
Background: Blood lipids are established risk factors for myocardial infarction (MI), but
uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating …
uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating …
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
Genome-wide association studies have identified numerous loci linked with complex
diseases, for which the molecular mechanisms remain largely unclear. Comprehensive …
diseases, for which the molecular mechanisms remain largely unclear. Comprehensive …
Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics
P Soininen, AJ Kangas, P Würtz, T Suna… - Circulation …, 2015 - ahajournals.org
Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …
quantitative profiling technologies and appealing results from their applications for …