Background Phenotypic heterogeneity is a major impediment to the elucidation of the
neurobiology and genetics of bipolar disorder. Endophenotype could help in reducing …

Advances in the understanding and management of bipolar disorder (BD) have been slow to
emerge. Despite notable recent developments in neurosciences, our conceptualization of …

Brain-derived neurotrophic factor (BDNF) is deemed to be associated with the
psychopathology of bipolar I disorder (BD). However, studies focusing on accuracy of BDNF …

Background Depression is a disabling and highly prevalent condition where genetic and
epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA …

Purpose Obesity is a complex and multifactorial disease identified as a global epidemic.
Convergent evidence indicates that obesity differentially influences patients with …

BackgroundBrain-derived neurotrophic factor (BDNF), which facilitates neuroplasticity and
synaptogenesis, may be decreased in bipolar disorder, but has not been systematically …

Bipolar disorder is a highly heritable and functionally impairing disease. The recognition and
intervention of BD especially that characterized by early onset remains challenging. Risk …

Neurotrophic factors and cardiorespiratory fitness are both considered important in
developmental trajectories but their link to brain health remains poorly understood. The aims …

Background In the current study, it was aimed to evaluate neurotrophic factor levels and their
relationship with executive functions in high-risk children and adolescents (high-risk group) …

Objectives This analysis aimed to investigate the association among interleukin 6 (IL-6)
levels, caloric intake, and working memory and to explore the potential mediators of these …