Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine
OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …
biological properties and diverse therapeutic applications in medicinal research. They are …
New quinoxaline-based VEGFR-2 inhibitors: Design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
A new series of 3-methylquinoxaline-based derivatives having the same essential
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR …
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4 (3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis …
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer.
Accordingly, new quinazoline-based derivatives having the structural features of VEGFR-2 …
Accordingly, new quinazoline-based derivatives having the structural features of VEGFR-2 …
Design and discovery of new 1,2,4‐triazolo[4,3‐c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors
Abstract A new series of 1, 2, 4‐triazolo [4, 3‐c] quinazoline derivatives was designed and
synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of the new …
synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of the new …
Design, synthesis and anticancer evaluation of 1H-pyrazolo [3, 4-d] pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers
In our attempt to develop effective EGFR-TKIs, two series of 1H-pyrazolo [3, 4-d] pyrimidine
derivatives were designed and synthesized. All the newly synthesized compounds were …
derivatives were designed and synthesized. All the newly synthesized compounds were …
Overview of chemistry and therapeutic potential of non-nitrogen heterocyclics as anticonvulsant agents
Epilepsy is a chronic neurological disorder, characterized by the predisposition of
unprovoked seizures affecting the neurobiological, psychological, cognitive, economic, and …
unprovoked seizures affecting the neurobiological, psychological, cognitive, economic, and …
Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers
As an extension for our earlier effort in the field of discovery of anticancer agents acting on
DNA and Topo II, eighteen quinoxaline derivatives were designed and synthesized. Such …
DNA and Topo II, eighteen quinoxaline derivatives were designed and synthesized. Such …
Discovery of new quinoxaline-based derivatives as anticancer agents and potent VEGFR-2 inhibitors: Design, synthesis, and in silico study
VEGFR-2 is one of the most vital targets for the treatment of solid tumors. This work
represents synthetic approaches of new set of quinoxaline-based derivatives having …
represents synthetic approaches of new set of quinoxaline-based derivatives having …