Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Proteasome inhibitors are rapidly evolving as potent treatment options in cancer therapy.
One of the most promising drug candidates of this type is salinosporamide A from the …

The ubiquitin–proteasome system is a major pathway for protein degradation, so that
proteasome is now considered as an important target for drug discovery. Bortezomib, the …

The Plasmodium falciparum proteasome constitutes a promising antimalarial target, with
multiple chemotypes potently and selectively inhibiting parasite proliferation and synergizing …

Dithiocarbamates are a class of metal-chelating compounds with various applications in
medicine. They have been used for the treatment of bacterial and fungal infections, possible …

Bacterial marine natural products are an important source of novel lead structures for drug
discovery. The cytotoxic properties of many of these secondary metabolites are of particular …

US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …

Connexin proteins are short-lived within the cell, whether present in the secretory pathway
or in gap junction plaques. Their levels can be modulated by their rate of degradation …

The cepafungins are a class of highly potent and selective eukaryotic proteasome inhibitor
natural products with potential to treat refractory multiple myeloma and other cancers. The …