Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy has been implicated in many physiological and pathological processes.
Accordingly, there is a growing scientific need to accurately identify, quantify, and …

Autophagy is a process of self-degradation of cellular components in which double-
membrane autophagosomes sequester organelles or portions of cytosol and fuse with …

Adenosine monophosphate–activated protein kinase (AMPK) is a conserved sensor of
intracellular energy activated in response to low nutrient availability and environmental …

Autophagy is the primary cellular catabolic program activated in response to nutrient
starvation. Initiation of autophagy, particularly by amino-acid withdrawal, requires the ULK …

Autophagy is a vital lysosomal degradation pathway that serves as a quality control
mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to …

Healthy cells use autophagy as a general'housekee**'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of
rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell …