Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: a systematic review

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Negative feedback control of neuronal activity by microglia

A Badimon, HJ Strasburger, P Ayata, X Chen, A Nair… - Nature, 2020 - nature.com
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

Targeting synapse function and loss for treatment of neurodegenerative diseases

B Dejanovic, M Sheng, JE Hanson - Nature Reviews Drug Discovery, 2024 - nature.com
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Effect of levetiracetam on cognition in patients with Alzheimer disease with and without epileptiform activity: a randomized clinical trial

K Vossel, KG Ranasinghe, AJ Beagle, A La… - JAMA …, 2021 - jamanetwork.com
Importance Network hyperexcitability may contribute to cognitive dysfunction in patients with
Alzheimer disease (AD). Objective To determine the ability of the antiseizure drug …

Epilepsy in older people

A Sen, N Jette, M Husain, JW Sander - The Lancet, 2020 - thelancet.com
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

F Maestú, W de Haan, MA Busche, J DeFelipe - Ageing Research Reviews, 2021 - Elsevier
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Mechanically tunable conductive interpenetrating network hydrogels that mimic the elastic moduli of biological tissue

VR Feig, H Tran, M Lee, Z Bao - Nature communications, 2018 - nature.com
Conductive and stretchable materials that match the elastic moduli of biological tissue (0.5–
500 kPa) are desired for enhanced interfacial and mechanical stability. Compared with …

Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease

BP Lucey, J Wisch, AH Boerwinkle, EC Landsness… - Brain, 2021 - academic.oup.com
Sleep monitoring may provide markers for future Alzheimer's disease; however, the
relationship between sleep and cognitive function in preclinical and early symptomatic …

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease

S Calafate, G Özturan, N Thrupp, J Vanderlinden… - Nature …, 2023 - nature.com
Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased
sleep quality. Here we show that homeostatic mechanisms transiently counteract the …