The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Rats and mice are widely used to study environmental effects on psychological and
metabolic health. Study designs differ widely and are often characterized by varying (social) …

High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity
and obesity related metabolic complications. In this study, we determined HFD induced …

Aim Our aim is to investigate the molecular mechanism of regulation of gene expression of
drug metabolizing enzymes (DMEs) and transporters in diet-induced obesity. Main methods …

Laboratory rodents are available as either genetically defined inbred strains or genetically
undefined outbred stocks. As outbred rodents are generally thought to display a higher level …

MicroRNAs (miRNAs) are short noncoding RNA implicated in the pathogenesis of obesity.
One cause of obesity is excess exposure to the saturated fatty acid palmitate that can alter …

Childhood obesity and obesity-related metabolic complications are induced by a high-fat
postnatal diet. The lack of a suitable animal model, however, remains a considerable …

Ulcerative colitis (UC) is a condition that has been rising in the number of cases around the
world. Food products made from natural ingredients such as corn and common bean might …

For (metabolic) research models using mice, singly housing is widely used for practical
purposes to study eg energy balance regulation and derangements herein. Mouse (social) …

Obesity causes innate immune dysfunction, contributing to increased disease risk. Weight
loss from a combination of caloric restriction and exercise is the most effective treatment of …