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Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation
Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …
Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13: discovery, application and engineering
J Franceus, T Desmet - International Journal of Molecular Sciences, 2020 - mdpi.com
Sucrose phosphorylases are carbohydrate-active enzymes with outstanding potential for the
biocatalytic conversion of common table sugar into products with attractive properties. They …
biocatalytic conversion of common table sugar into products with attractive properties. They …
Asymmetric synthesis of 3-pyrrole substituted β-lactams through p-toluene sulphonic acid-catalyzed reaction of azetidine-2, 3-diones with hydroxyprolines
Aims: The aim of this study is to investigate the p-toluene sulphonic acid (p-Ts. OH)-
catalyzed reaction of racemic-azetidine-2, 3-diones with enantiomerically pure cis and trans …
catalyzed reaction of racemic-azetidine-2, 3-diones with enantiomerically pure cis and trans …
Expanding the Chemical Space of Electrophilic β-Glycosyl β-Lactams through Photoinduced Diastereoselective Functionalization
ÉA Tordato, RO Gonçalves, LL Baldassari… - Organic …, 2024 - ACS Publications
Herein, we present a photoinduced diastereoselective C-3 functionalization of electrophilic β-
glycosyl β-lactams. The developed protocol is simple, mild, and scalable and explores the …
glycosyl β-lactams. The developed protocol is simple, mild, and scalable and explores the …
Substituted phenethylamine-based β-lactam derivatives: Antimicrobial, anticancer, and β-lactamase inhibitory properties
In this study, a series of novel β-lactam derivatives were synthesized with yields ranging
from 41% to 91%, and their antimicrobial activities were investigated against bacterial and …
from 41% to 91%, and their antimicrobial activities were investigated against bacterial and …
Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK
Complex carbapenems are important clinical antibiotics for difficult-to-treat infections. An
essential step in the biosyntheses of these natural products is stereospecific methylation at …
essential step in the biosyntheses of these natural products is stereospecific methylation at …
Ni-Catalyzed asymmetric reduction of α-keto-β-lactams via DKR enabled by proton shuttling
F Wang, X Tan, T Wu, LS Zheng, GQ Chen… - Chemical …, 2020 - pubs.rsc.org
Chiral α-hydroxy-β-lactams are key fragments of many bioactive compounds and antibiotics,
and the development of efficient synthetic methods for these compounds is of great value …
and the development of efficient synthetic methods for these compounds is of great value …
[HTML][HTML] Structural Comparison of a Promiscuous and a Highly Specific Sucrose 6F-Phosphate Phosphorylase
J Franceus, N Capra, T Desmet… - International Journal of …, 2019 - mdpi.com
In family GH13 of the carbohydrate-active enzyme database, subfamily 18 contains
glycoside phosphorylases that act on α-sugars and glucosides. Because their …
glycoside phosphorylases that act on α-sugars and glucosides. Because their …
Hypervalent iodine (iii) induced oxidative olefination of benzylamines using Wittig reagents
We have developed hypervalent iodine (III) induced oxidative olefination of primary and
secondary benzylamines using 2C-Wittig reagents, which provides easy access to α, β …
secondary benzylamines using 2C-Wittig reagents, which provides easy access to α, β …
Antibacterial properties of substituted phenethylamine-based β-lactam derivatives in oral infections
M Yildirim, E Aksakal, TY Bayram, E Irmak… - The European …, 2025 - euchembioj.com
Oral infections are a type of infection that occurs in and around the mouth, typically arising
when proper oral hygiene is neglected. These infections manifest as symptoms such as …
when proper oral hygiene is neglected. These infections manifest as symptoms such as …