Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation

UM Vasudevan, EY Lee - Biotechnology advances, 2020 - Elsevier
Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …

Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13: discovery, application and engineering

J Franceus, T Desmet - International Journal of Molecular Sciences, 2020 - mdpi.com
Sucrose phosphorylases are carbohydrate-active enzymes with outstanding potential for the
biocatalytic conversion of common table sugar into products with attractive properties. They …

Asymmetric synthesis of 3-pyrrole substituted β-lactams through p-toluene sulphonic acid-catalyzed reaction of azetidine-2, 3-diones with hydroxyprolines

RN Yadav, AL Shaikh, A Das, D Ray… - Current …, 2022 - benthamdirect.com
Aims: The aim of this study is to investigate the p-toluene sulphonic acid (p-Ts. OH)-
catalyzed reaction of racemic-azetidine-2, 3-diones with enantiomerically pure cis and trans …

Expanding the Chemical Space of Electrophilic β-Glycosyl β-Lactams through Photoinduced Diastereoselective Functionalization

ÉA Tordato, RO Gonçalves, LL Baldassari… - Organic …, 2024 - ACS Publications
Herein, we present a photoinduced diastereoselective C-3 functionalization of electrophilic β-
glycosyl β-lactams. The developed protocol is simple, mild, and scalable and explores the …

Substituted phenethylamine-based β-lactam derivatives: Antimicrobial, anticancer, and β-lactamase inhibitory properties

M Yildirim, B Ozgeris, A Gormez - Bioorganic chemistry, 2022 - Elsevier
In this study, a series of novel β-lactam derivatives were synthesized with yields ranging
from 41% to 91%, and their antimicrobial activities were investigated against bacterial and …

Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK

MS Lichstrahl, CA Townsend, EK Sinner - RSC Chemical Biology, 2022 - pubs.rsc.org
Complex carbapenems are important clinical antibiotics for difficult-to-treat infections. An
essential step in the biosyntheses of these natural products is stereospecific methylation at …

Ni-Catalyzed asymmetric reduction of α-keto-β-lactams via DKR enabled by proton shuttling

F Wang, X Tan, T Wu, LS Zheng, GQ Chen… - Chemical …, 2020 - pubs.rsc.org
Chiral α-hydroxy-β-lactams are key fragments of many bioactive compounds and antibiotics,
and the development of efficient synthetic methods for these compounds is of great value …

[HTML][HTML] Structural Comparison of a Promiscuous and a Highly Specific Sucrose 6F-Phosphate Phosphorylase

J Franceus, N Capra, T Desmet… - International Journal of …, 2019 - mdpi.com
In family GH13 of the carbohydrate-active enzyme database, subfamily 18 contains
glycoside phosphorylases that act on α-sugars and glucosides. Because their …

Hypervalent iodine (iii) induced oxidative olefination of benzylamines using Wittig reagents

V Ramavath, BD Rupanawar, SG More… - New Journal of …, 2021 - pubs.rsc.org
We have developed hypervalent iodine (III) induced oxidative olefination of primary and
secondary benzylamines using 2C-Wittig reagents, which provides easy access to α, β …

Antibacterial properties of substituted phenethylamine-based β-lactam derivatives in oral infections

M Yildirim, E Aksakal, TY Bayram, E Irmak… - The European …, 2025 - euchembioj.com
Oral infections are a type of infection that occurs in and around the mouth, typically arising
when proper oral hygiene is neglected. These infections manifest as symptoms such as …