Bacterial exopolysaccharides: biosynthesis pathways and engineering strategies

J Schmid, V Sieber, B Rehm - Frontiers in microbiology, 2015 - frontiersin.org
Bacteria produce a wide range of exopolysaccharides which are synthesized via different
biosynthesis pathways. The genes responsible for synthesis are often clustered within the …

Strategies for enhancing microbial production of 2′-fucosyllactose, the most abundant human milk oligosaccharide

Y Liu, Y Zhu, H Wang, L Wan, W Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Human milk oligosaccharides (HMOs), a group of structurally diverse unconjugated glycans
in breast milk, act as important prebiotics and have plenty of unique health effects for …

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

J He, Q Shi, Z Chen, W Zhang, P Lan, Q Xu, H Hu… - Drug Resistance …, 2023 - Elsevier
Aims To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64
carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and …

Characterization of phage resistance and phages capable of intestinal decolonization of carbapenem-resistant Klebsiella pneumoniae in mice

Q Fang, Y Feng, A McNally, Z Zong - Communications Biology, 2022 - nature.com
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a severe global
health challenge. We isolate and characterize two previously unidentified lytic phages, P24 …

Dead‐end intermediates in the enterobacterial common antigen pathway induce morphological defects in Escherichia coli by competing for undecaprenyl phosphate

MA Jorgenson, S Kannan, ME Laubacher… - Molecular …, 2016 - Wiley Online Library
Bacterial morphology is determined primarily by the architecture of the peptidoglycan (PG)
cell wall, a mesh‐like layer that encases the cell. To identify novel mechanisms that create or …

Persister cells resuscitate using membrane sensors that activate chemotaxis, lower cAMP levels, and revive ribosomes

R Yamasaki, S Song, MJ Benedik, TK Wood - Iscience, 2020 - cell.com
Persistence, the stress-tolerant state, is arguably the most vital phenotype since nearly all
cells experience nutrient stress, which causes a sub-population to become dormant …

A Frameshift Mutation in wcaJ Associated with Phage Resistance in Klebsiella pneumoniae

D Tan, Y Zhang, J Qin, S Le, J Gu, L Chen, X Guo… - Microorganisms, 2020 - mdpi.com
Phage therapy is a potential and promising avenue for controlling the emergence and
spread of multidrug-resistant (MDR) Klebsiella pneumoniae, however, the rapid …

Disrupting gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA

MK Alexander, A Miu, A Oh, M Reichelt… - Antimicrobial Agents …, 2018 - journals.asm.org
There is a critical need for new antibacterial strategies to counter the growing problem of
antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a …

[HTML][HTML] Colanic acid biosynthesis in Escherichia coli is dependent on lipopolysaccharide structure and glucose availability

C Wang, H Zhang, J Wang, S Chen, Z Wang… - Microbiological …, 2020 - Elsevier
Lipopolysaccharide and colanic acid are important forms of exopolysaccharides located on
the cell surface of Escherichia coli, but their interrelation with the cell stress response is not …

Characterization of the exopolysaccharide biosynthesis pathway in Myxococcus xanthus

M Pérez-Burgos, I García-Romero, J Jung… - Journal of …, 2020 - journals.asm.org
Myxococcus xanthus arranges into two morphologically distinct biofilms depending on its
nutritional status, ie, coordinately spreading colonies in the presence of nutrients and spore …