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Bacterial exopolysaccharides: biosynthesis pathways and engineering strategies
Bacteria produce a wide range of exopolysaccharides which are synthesized via different
biosynthesis pathways. The genes responsible for synthesis are often clustered within the …
biosynthesis pathways. The genes responsible for synthesis are often clustered within the …
Strategies for enhancing microbial production of 2′-fucosyllactose, the most abundant human milk oligosaccharide
Y Liu, Y Zhu, H Wang, L Wan, W Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Human milk oligosaccharides (HMOs), a group of structurally diverse unconjugated glycans
in breast milk, act as important prebiotics and have plenty of unique health effects for …
in breast milk, act as important prebiotics and have plenty of unique health effects for …
Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae
J He, Q Shi, Z Chen, W Zhang, P Lan, Q Xu, H Hu… - Drug Resistance …, 2023 - Elsevier
Aims To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64
carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and …
carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and …
Characterization of phage resistance and phages capable of intestinal decolonization of carbapenem-resistant Klebsiella pneumoniae in mice
Q Fang, Y Feng, A McNally, Z Zong - Communications Biology, 2022 - nature.com
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a severe global
health challenge. We isolate and characterize two previously unidentified lytic phages, P24 …
health challenge. We isolate and characterize two previously unidentified lytic phages, P24 …
Dead‐end intermediates in the enterobacterial common antigen pathway induce morphological defects in Escherichia coli by competing for undecaprenyl phosphate
Bacterial morphology is determined primarily by the architecture of the peptidoglycan (PG)
cell wall, a mesh‐like layer that encases the cell. To identify novel mechanisms that create or …
cell wall, a mesh‐like layer that encases the cell. To identify novel mechanisms that create or …
Persister cells resuscitate using membrane sensors that activate chemotaxis, lower cAMP levels, and revive ribosomes
Persistence, the stress-tolerant state, is arguably the most vital phenotype since nearly all
cells experience nutrient stress, which causes a sub-population to become dormant …
cells experience nutrient stress, which causes a sub-population to become dormant …
A Frameshift Mutation in wcaJ Associated with Phage Resistance in Klebsiella pneumoniae
Phage therapy is a potential and promising avenue for controlling the emergence and
spread of multidrug-resistant (MDR) Klebsiella pneumoniae, however, the rapid …
spread of multidrug-resistant (MDR) Klebsiella pneumoniae, however, the rapid …
Disrupting gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
MK Alexander, A Miu, A Oh, M Reichelt… - Antimicrobial Agents …, 2018 - journals.asm.org
There is a critical need for new antibacterial strategies to counter the growing problem of
antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a …
antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a …
[HTML][HTML] Colanic acid biosynthesis in Escherichia coli is dependent on lipopolysaccharide structure and glucose availability
C Wang, H Zhang, J Wang, S Chen, Z Wang… - Microbiological …, 2020 - Elsevier
Lipopolysaccharide and colanic acid are important forms of exopolysaccharides located on
the cell surface of Escherichia coli, but their interrelation with the cell stress response is not …
the cell surface of Escherichia coli, but their interrelation with the cell stress response is not …
Characterization of the exopolysaccharide biosynthesis pathway in Myxococcus xanthus
M Pérez-Burgos, I García-Romero, J Jung… - Journal of …, 2020 - journals.asm.org
Myxococcus xanthus arranges into two morphologically distinct biofilms depending on its
nutritional status, ie, coordinately spreading colonies in the presence of nutrients and spore …
nutritional status, ie, coordinately spreading colonies in the presence of nutrients and spore …