Poor solubility of new drugs and their related low oral bioavailability and general delivery
problems are becoming a major challenge. Nanocrystals being a kind of “universal” …

Poor water solubility for many drugs and drug candidates remains a major obstacle to their
development and clinical application. Conventional formulations to improve solubility suffer …

Drug design in recent years has attempted to explore new chemical spaces resulting in
more complex, larger molecular weight molecules, often with limited water solubility. To …

Hydrophilic nanogels combine the advantages of hydrogels with certain advantages that are
inherent in their nanoscale size. Similar to macrogels, nanogels can contain and protect …

It is estimated that more than 40% of new chemical entities (NCEs) coming out of the current
drug discovery process have poor biopharmaceutical properties, such as low aqueous …

Triterpenoids are structurally diverse organic compounds that exist widely as natural
products. Triterpenoids and their derivatives possess a wide range of biological effects …

Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to
their dissolution rate inadequate to treat the pathology of interest. A large drug particle size …

Nanocrystals (NCs) are the class of solid dosage forms which utilizes the concept of
nanoscience together with crystal nature of drug to achieve advantages in terms of solubility …

Most of the active pharmaceutical ingredient used in the management of disease have poor
water solubility and offer grueling problems in drug formulation development since low …

Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical
development. Pharmaceutical development of drugs with poor water solubility requires the …