Vitamin E: a role in signal transduction

JM Zingg - Annual review of nutrition, 2015 - annualreviews.org
Vitamin E modulates the activity of several signal transduction enzymes with consequent
alterations of gene expression. At the molecular level, vitamin E may directly bind to these …

Regulation of obesity and metabolic complications by gamma and delta tocotrienols

L Zhao, X Fang, MR Marshall, S Chung - Molecules, 2016 - mdpi.com
Tocotrienols (T3s) are a subclass of unsaturated vitamin E that have been extensively
studied for their anti-proliferative, anti-oxidative and anti-inflammatory properties in …

Tocotrienol and its role in chronic diseases

KY Chin, KL Pang, IN Soelaiman - Anti-inflammatory nutraceuticals and …, 2016 - Springer
Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-
inflammatory properties. It is also a suppressor of mevalonate pathway responsible for …

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

A Amanullah, A Upadhyay, V Joshi, R Mishra… - Progress in …, 2017 - Elsevier
Proteins are ordered useful cellular entities, required for normal health and organism's
survival. The proteome is the absolute set of cellular expressed proteins, which regulates a …

α‐Tocopheryl phosphate—An activated form of vitamin E important for angiogenesis and vasculogenesis?

JM Zingg, M Meydani, A Azzi - Biofactors, 2012 - Wiley Online Library
Vitamin E was originally discovered as a dietary factor essential for reproduction in rats.
Since then, vitamin E has revealed many important molecular properties such as the …

Modulation of gene expression by α-tocopherol and α-tocopheryl phosphate in THP-1 monocytes

JM Zingg, R Libinaki, CQ Lai, M Meydani… - Free Radical Biology …, 2010 - Elsevier
The natural vitamin E analog α-tocopheryl phosphate (αTP) modulates atherosclerotic and
inflammatory events more efficiently than the unphosphorylated α-tocopherol (αT). To …

Induction of VEGF expression by alpha‐tocopherol and alpha‐tocopheryl phosphate via PI3Kγ/PKB and hTAP1/SEC14L2‐mediated lipid exchange

JM Zingg, A Azzi, M Meydani - Journal of cellular biochemistry, 2015 - Wiley Online Library
In several studies, vitamin E has been observed to influence angiogenesis and
vasculogenesis. We recently showed that the phosphorylated form of α‐tocopherol (αT), α …

α‐Tocopheryl phosphate–An active lipid mediator?

JM Zingg, M Meydani, A Azzi - Molecular nutrition & food …, 2010 - Wiley Online Library
The vitamin E (α‐tocopherol, αT) derivative, α‐tocopheryl phosphate (αTP), is detectable in
small amounts in plasma, tissues, and cultured cells. Studies done in vitro and in vivo …

Modulation of phosphorylation of tocopherol and phosphatidylinositol by hTAP1/SEC14L2-mediated lipid exchange

JM Zingg, R Libinaki, M Meydani, A Azzi - PLoS One, 2014 - journals.plos.org
The vitamin E derivative, alpha-tocopheryl phosphate (αTP), is detectable in cultured cells,
plasma and tissues in small amounts, suggesting the existence of enzyme (s) with α …

High‐throughput profiling reveals perturbation of endoplasmic reticulum stress‐related genes in atherosclerosis induced by high‐cholesterol diet and the protective …

P Bozaykut, R Ekren, OU Sezerman, VN Gladyshev… - …, 2020 - Wiley Online Library
Formation of atherosclerotic plaques, called atherogenesis, is a complex process affected by
genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is …