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Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …
fourth-leading cause of death. Hyperglycemia induces various complications, including …
Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy
A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up
and accumulated specifically in cancer cells without chemical conjugation have recently …
and accumulated specifically in cancer cells without chemical conjugation have recently …
Sequential nano-penetrators of capillarized liver sinusoids and extracellular matrix barriers for liver fibrosis therapy
LF Zhang, XH Wang, CL Zhang, J Lee, BW Duan… - ACS …, 2022 - ACS Publications
During liver fibrogenesis, liver sinusoidal capillarization and extracellular matrix (ECM)
deposition construct dual pathological barriers to drug delivery. Upon capillarization, the …
deposition construct dual pathological barriers to drug delivery. Upon capillarization, the …
Hyaluronan as a therapeutic target in human diseases
Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …
Hyaluronate and its derivatives for customized biomedical applications
Since hyaluronate (HA) was firstly isolated from the vitreous of bovine eyes in 1934, HA has
been widely investigated for various biomedical applications. As a naturally-occurring …
been widely investigated for various biomedical applications. As a naturally-occurring …
Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells
S **a, Z Liu, J Cai, H Ren, Q Li, H Zhang, J Yue… - Journal of Controlled …, 2023 - Elsevier
Liver fibrosis is one of the most common liver diseases with substantial morbidity and
mortality. However, effective therapy for liver fibrosis is still lacking. Considering the key …
mortality. However, effective therapy for liver fibrosis is still lacking. Considering the key …
Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid
Polymer–drug conjugates have demonstrated application potentials in optimizing
chemotherapeutics. In this study a new bioconjugate, HA-ss-PTX, was designed and …
chemotherapeutics. In this study a new bioconjugate, HA-ss-PTX, was designed and …
Hyaluronic acid derivatives for translational medicines
The recent progress in various biomaterials with unique physiological and pharmacological
properties has expedited the development of translational medicines for the diagnosis …
properties has expedited the development of translational medicines for the diagnosis …
Hyaluronate Epidermal Growth Factor Conjugate for Skin Wound Healing and Regeneration
Epidermal growth factor (EGF) has been recognized as an excellent wound healing agent
due to its therapeutic function stimulating skin cell growth, proliferation and differentiation …
due to its therapeutic function stimulating skin cell growth, proliferation and differentiation …
Targeted drug delivery to hepatic stellate cells for the treatment of liver fibrosis
Liver fibrosis is caused by excessive accumulation of extracellular matrix during chronic liver
injuries. Although clinical evidence suggests that liver fibrosis can be reversed, there is no …
injuries. Although clinical evidence suggests that liver fibrosis can be reversed, there is no …