[HTML][HTML] Transcriptional regulation and its misregulation in disease
TI Lee, RA Young - Cell, 2013 - cell.com
The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …
Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - Elsevier
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
Cancer cells possess traits reminiscent of those ascribed to normal stem cells. It is unclear,
however, whether these phenotypic similarities reflect the activity of common molecular …
however, whether these phenotypic similarities reflect the activity of common molecular …
[HTML][HTML] Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
Cancer cells within individual tumors often exist in distinct phenotypic states that differ in
functional attributes. While cancer cell populations typically display distinctive equilibria in …
functional attributes. While cancer cell populations typically display distinctive equilibria in …
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
The utility of induced pluripotent stem (iPS) cells for investigating the molecular logic of
pluripotency and for eventual clinical application is limited by the low efficiency of current …
pluripotency and for eventual clinical application is limited by the low efficiency of current …
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by
reprogramming is accompanied by a global remodeling of the epigenome,,,,, resulting in …
reprogramming is accompanied by a global remodeling of the epigenome,,,,, resulting in …
Characterising and predicting haploinsufficiency in the human genome
Haploinsufficiency, wherein a single functional copy of a gene is insufficient to maintain
normal function, is a major cause of dominant disease. Human disease studies have …
normal function, is a major cause of dominant disease. Human disease studies have …
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
L Lapasset, O Milhavet, A Prieur… - Genes & …, 2011 - genesdev.cshlp.org
Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a
unique opportunity to derive patient-specific stem cells with potential applications in tissue …
unique opportunity to derive patient-specific stem cells with potential applications in tissue …
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
K Amps, PW Andrews, G Anyfantis… - Nature …, 2011 - search.ebscohost.com
Abstract The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
Critical function of Prdm14 for the establishment of the germ cell lineage in mice
Abstract Specification of germ cell fate is fundamental in development and heredity. Recent
evidence indicates that in mice, specification of primordial germ cells (PGCs), the common …
evidence indicates that in mice, specification of primordial germ cells (PGCs), the common …