Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

In the last decade or so, polychlorinated biphenyls (PCBs) garnered renewed attention in
the scientific community due to new evidence pointing at their continued presence in the …

The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Background Tapinarof cream is a topical aryl hydrocarbon receptor–modulating agent under
investigation for the treatment of psoriasis. Tapinarof modulates the expression of interleukin …

Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …

Tryptophan catabolism by the enzymes indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-
dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The …

The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …