Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …

Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

Background Hypoxia is a major cause of beta cell death and dysfunction after
transplantation. The aim of this study was to investigate the effect of exosomes derived from …

Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …

Biomaterials play a pivotal role in field of tissue engineering. Biomimetic synthetic polymers
have been created to elicit specific cellular functions and to direct cell-cell interactions both …

A major hindrance in engineering tissues containing highly metabolically active cells is the
insufficient oxygenation of these implants, which results in dying or dysfunctional cells in …

Insulin therapy became a reality in 1921 dramatically saving lives of people with diabetes,
but not protecting them from long-term complications. Clinically successful free islet implants …

Abstract Purpose of Review To provide an overview of the mechanistic and epidemiologic
evidence linking sleep-related exposures, such as short sleep duration, obstructive sleep …

Transplantation of pancreatic islets is emerging as a successful treatment for type-1
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …

In the past two decades, many polymers have been proposed for producing
immunoprotective capsules. Examples include the natural polymers alginate, agarose …