Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …

Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum,
trabecular bone, adipose tissue, synovium, skeletal muscle and deciduous teeth. These …

Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the
molecular basis for this is unknown. Here, we report a critical role for the osteoclastic …

Dyslipidemia and insulin resistance are commonly associated with catabolic or
lipodystrophic conditions (such as cancer and sepsis) and with pathological states of …

Constitutively activated NF-κB occurs in many inflammatory and tumor tissues. Does it
interfere with anti-inflammatory or anti-tumor signaling pathway? Here, we report that NF-κB …

Extensive research within the past two decades has revealed that obesity, a major risk factor
for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a …

Insulin signalling is uniquely required for storing energy as fat in humans. While de novo
synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary …

Nuclear factor (NF)-κB is a family of seven structurally related transcription factors that play a
central role in cardiovascular growth, stress response, and inflammation by controlling gene …

Osteoblasts and adipocytes differentiate from a common pluripotent precursor, the
mesenchymal stem cell (MSC). Studies have identified numerous transcription factors, and …