ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform
mechanical work during targeted protein degradation within cells. ClpXP consists of …

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that
are of key importance to cell fate. The unique molecular architecture of the widely conserved …

As nascent polypeptides exit ribosomes, they are engaged by a series of processing,
targeting, and folding factors. Here, we present a selective ribosome profiling strategy that …

The heat-shock response is a mechanism of cellular protection against sudden adverse
environmental growth conditions and results in the prompt production of various heat-shock …

The Gram-negative bacterial envelope is an essential interface between the intracellular
and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the …

In enteric bacteria, the transcription factor σE maintains membrane homeostasis by inducing
synthesis of proteins involved in membrane repair and two small regulatory RNAs (sRNAs) …

Extracytoplasmic function σ factors (ECFs) represent a fundamental and widely distributed
principle of bacterial signal transduction that connects the perception of a stimulus (input) …

Protein quality control involves sensing and treatment of defective or incomplete protein
structures. Misfolded or mislocalized proteins trigger dedicated signal transduction cascades …

The signal transduction pathway governing the σE-dependent cell envelope stress response
in Escherichia coli communicates information from the periplasm to σE in the cytoplasm via a …

A vast range of extracellular polysaccharides are produced by bacteria in order to adapt to
and thrive in diverse environmental niches. Many of these polymers have attracted great …