Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …

Single-cell transcriptomics can profile thousands of cells in a single experiment and identify
novel cell types, states and dynamics in a wide variety of tissues and organisms. Standard …

Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms,–. However, an unbiased understanding of the …

Single-cell RNA sequencing has enabled the characterization of highly specific cell types in
many tissues, as well as both primary and stem cell-derived cell lines. An important facet of …

INTRODUCTION Cross-linking of high-affinity, allergen-specific immunoglobulin E (IgE) on
mast cells results in anaphylaxis, a potentially life-threatening allergic reaction. The cellular …

Background The analysis of single-cell RNA sequencing (scRNAseq) data plays an
important role in understanding the intrinsic and extrinsic cellular processes in biological …

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

Cells from the same individual share common genetic and environmental backgrounds and
are not statistically independent; therefore, they are subsamples or pseudoreplicates. Thus …

As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the
number of tools designed to analyse these data has dramatically increased. Navigating the …

Background A fundamental fact in biology states that genes do not operate in isolation, and
yet, methods that infer regulatory networks for single cell gene expression data have been …