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Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia
HC Su, H **g, Y Zhang… - Annual review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …
have been gained into virus biology and the host factors that modulate the human immune …
Three-year outcomes of post-acute sequelae of COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-
acute sequelae of coronavirus disease 2019 (COVID-19)(PASC) in many organ systems …
acute sequelae of coronavirus disease 2019 (COVID-19)(PASC) in many organ systems …
Early treatment with pegylated interferon lambda for Covid-19
Background The efficacy of a single dose of pegylated interferon lambda in preventing
clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid …
clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid …
[HTML][HTML] The Penn Medicine BioBank: towards a genomics-enabled learning healthcare system to accelerate precision medicine in a diverse population
The Penn Medicine BioBank (PMBB) is an electronic health record (EHR)-linked biobank at
the University of Pennsylvania (Penn Medicine). A large variety of health-related information …
the University of Pennsylvania (Penn Medicine). A large variety of health-related information …
Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
In response to viral infection, how cells balance translational shutdown to limit viral
replication and the induction of antiviral components like interferons (IFNs) is not well …
replication and the induction of antiviral components like interferons (IFNs) is not well …
The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation
An important property of the host innate immune response during microbial infection is its
ability to control the expression of antimicrobial effector proteins, but how this occurs post …
ability to control the expression of antimicrobial effector proteins, but how this occurs post …
Interferon at the crossroads of SARS-CoV-2 infection and COVID-19 disease
A novel coronavirus now known as SARS-CoV-2 emerged in late 2019, possibly following a
zoonotic crossover from a coronavirus present in bats. This virus was identified as the …
zoonotic crossover from a coronavirus present in bats. This virus was identified as the …
Innate immune responses to RNA: sensing and signaling
Nucleic acids are among the most essential PAMPs (pathogen-associated molecular
patterns). Animals have evolved numerous sensors to recognize nucleic acids and trigger …
patterns). Animals have evolved numerous sensors to recognize nucleic acids and trigger …
Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer
Understanding the complex background of cancer requires genotype-phenotype information
in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA …
in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA …