Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Sudden cardiac death, frequently due to ventricular arrhythmias, is a significant problem
globally. Most affected individuals do not arrive at hospital in time for medical treatment …

It has become widely accepted that the most dangerous cardiac arrhythmias are due to
reentrant waves, ie, electrical wave (s) that recirculate repeatedly throughout the tissue at a …

Short QT syndrome (SQTS) leads to an abbreviated QTc interval and predisposes patients to
life-threatening arrhythmias. To date, two forms of the disease have been identified: SQT1 …

Modeling the dynamics of wave propagation in human ventricular tissue and studying wave
stability require models that reproduce realistic characteristics in tissue. We present a …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …

Computer simulations and nonlinear dynamics have provided invaluable tools for
illuminating the underlying mechanisms of cardiac arrhythmias. Here, we review how this …