Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pum** throughout the mammal's lifespan. This process is …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Tumor-infiltrating neoantigen-reactive T cells can mediate regression of metastatic
gastrointestinal cancers yet remain poorly characterized. We performed immunological …

Cardiac differentiation of human pluripotent stem cells (hPSCs) requires orchestration of
dynamic gene regulatory networks during stepwise fate transitions but often generates …

Intestinal epithelial stem cell identity and location have been the subject of substantial
research. Cells in the+ 4 niche are slow-cycling and label-retaining, whereas a different …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …

Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as
important regulators of gene expression. Here, we investigated the function and molecular …