Complexes of ruthenium (II) as promising dual-active agents against cancer and viral infections
Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …
frequency diseases, such as cancer and viral infections, have been widely documented. In …
Interweaving catalysis and cancer using Ru-and Os-arene complexes to alter cellular redox state: A structure-activity relationship (SAR) review
The field of bioorganometallic chemistry has expanded significantly in the recent past.
Organometallic complexes have offered up new opportunities as efficient catalysts (such as …
Organometallic complexes have offered up new opportunities as efficient catalysts (such as …
Investigating the anticancer potential of 4-phenylthiazole derived Ru (ii) and Os (ii) metalacycles
P Getreuer, L Marretta, E Toyoglu, O Dömötör… - Dalton …, 2024 - pubs.rsc.org
In this contribution we report the synthesis, characterization and in vitro anticancer activity of
novel cyclometalated 4-phenylthiazole-derived ruthenium (II)(2a–e) and osmium (II)(3a–e) …
novel cyclometalated 4-phenylthiazole-derived ruthenium (II)(2a–e) and osmium (II)(3a–e) …
In Vitro and In Vivo Anticancer Activities of Water-Soluble Ru(II)(η6-p-cymene) Complexes via Activating Apoptosis Central Regulators and Possibilities of New …
S Man, H Ren, Y Li, J Li, C Zou, AJ Khan… - Journal of Medicinal …, 2025 - ACS Publications
In this study, we synthesized 12 monofunctional tridentate ONS-donor salicylaldimine ligand
(L)-based Ru (II) complexes with general formula [(Ru (L)(p-cymene)]+· Cl–(C1-C12) …
(L)-based Ru (II) complexes with general formula [(Ru (L)(p-cymene)]+· Cl–(C1-C12) …
Anticancer Tungstenocenes with a Diverse Set of (O,O–), (O,S–) and (O,N–) Chelates—A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid …
K Cseh, I Berasaluce, V Fuchs, A Banc, A Schweikert… - Pharmaceutics, 2023 - mdpi.com
The synthesis, characterization and biological activity of tungstenocenes with varying
biologically active (O, O–),(S, O–) and (N, O–) chelates are described. Complexes were …
biologically active (O, O–),(S, O–) and (N, O–) chelates are described. Complexes were …
[HTML][HTML] Platinum (IV)-Loaded Degraded Glycol Chitosan as Efficient Platinum (IV) Drug Delivery Platform
Y Lerchbammer-Kreith, NS Sommerfeld, K Cseh… - Pharmaceutics, 2023 - mdpi.com
A new class of anticancer prodrugs was designed by combining the cytotoxicity of platinum
(IV) complexes and the drug carrier properties of glycol chitosan polymers: Unsymmetrically …
(IV) complexes and the drug carrier properties of glycol chitosan polymers: Unsymmetrically …
Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum (IV) Complexes—A More Selective Anticancer Treatment?
Y Lerchbammer-Kreith, M Hejl, P Vician, MA Jakupec… - Pharmaceutics, 2023 - mdpi.com
Based on their drug delivery properties and activity against tumors, we combined PAMAM
dendrimers with various platinum (IV) complexes in order to provide an improved approach …
dendrimers with various platinum (IV) complexes in order to provide an improved approach …
Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice
V Fuchs, K Cseh, M Hejl, P Vician… - … A European Journal, 2023 - Wiley Online Library
A series of six highly lipophilic Cp‐substituted molybdenocenes bearing different bioactive
chelating ligands was synthesized and characterized by NMR spectroscopy, mass …
chelating ligands was synthesized and characterized by NMR spectroscopy, mass …
Synthesis and Antiproliferative Activity of Cisplatin‐3–Chloropiperidine Conjugates
M Georg, AA Legin, M Hejl, MA Jakupec… - …, 2024 - Wiley Online Library
We report the synthesis and characterization of two novel cisplatin‐alkylating agents
conjugates. Combining a platinum based cytostatic agent with a sterically demanding …
conjugates. Combining a platinum based cytostatic agent with a sterically demanding …
Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents—A Novel Polymer Formulation for Anticancer Therapy
Y Lerchbammer-Kreith, M Hejl, NS Sommerfeld… - Pharmaceuticals, 2023 - mdpi.com
Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug
delivery properties and has been studied as a carrier for anticancer agents. Consequently …
delivery properties and has been studied as a carrier for anticancer agents. Consequently …