Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Oxygen is essential for the life of most multicellular organisms. Cells possess enzymes
called molecular dioxygenases that depend on oxygen for activity. A subclass of molecular …

Response rates to immunotherapy in solid tumors remain low due in part to the elevated
prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced …

Oxygen sensing is central to metazoan biology and has implications for human disease.
Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG) …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Fusobacterium nucleatum, a gram-negative oral bacterium, has been consistently validated
as a strong contributor to the progression of several types of cancer, including colorectal …

Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to
the mechanisms controlling cellular responses under such stress stimuli, are the …

Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

The importance of oxygen for the survival of multicellular and aerobic organisms is well
established and documented. Over the years, increased knowledge of its use for …