Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Proteinase-activated receptors are a recently described, novel family of seven-
transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand …

In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

Mast cells, which are granulocytes found in peripheral tissue, play a central role in
inflammatory and immediate allergic reactions. β‐Tryptase is a neutral serine protease and …

Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …

Proteinase-activated receptor (PAR)-2, a G-protein-coupled receptor for trypsin and mast
cell tryptase, is highly expressed in the intestine. Luminal trypsin and tryptase are elevated …

Background: Protease-activated receptors (PARs), which are G protein–coupled receptors
that are activated after proteolytic cleavage of the amino terminus of the receptor, are likely …

Endothelial surface expression of P-selectin and subsequent leukocyte rolling in venules
can be induced by mast cell-derived histamine and binding of thrombin to protease …

Thrombin signaling in the endothelium is linked to multiple phenotypic changes, including
alterations in permeability, vasomotor tone, and leukocyte trafficking. The thrombin signal is …

Proteinase-activated receptor 2 (PAR 2), a seven-transmembrane G protein-coupled
receptor, is activated at inflammatory sites by proteolytic cleavage of its extracellular N …